High ionic strength depresses muscle contractility by decreasing both force per cross-bridge and the number of strongly attached cross-bridges
نویسندگان
چکیده
منابع مشابه
Muscle cross-bridge chemistry and force.
The recent article by Baker et al. (1999) presents a thermo-dynamic formalism that challenges the commonly held assumption that force production by muscle is localized to individual actin-bound myosin molecules. By assuming that the chemical reaction for the force-producing step is close enough to equilibrium to set ⌬G ϭ 0, the sum of the chemical and mechanical potentials of the products can b...
متن کاملInfluence of residual force enhancement and elongation of attached cross‐bridges on stretch‐shortening cycle in skinned muscle fibers
Increased muscle force during stretch-shortening cycles (SSCs) has been widely examined. However, the mechanisms causing increased muscle force in SSCs remain unknown. The purpose of this study was to determine the influence of residual force enhancement and elongation of attached cross-bridges on the work enhancement in SSCs. For the Control condition, skinned rabbit soleus fibers were elongat...
متن کاملShortening-induced force depression is primarily caused by cross-bridges in strongly bound states.
The steady-state isometric force following active muscle shortening is smaller than the corresponding force obtained for purely isometric contractions. This so-called residual force depression has been observed consistently for more than half a century, however its mechanism remains a matter of scientific debate. [Maréchal, G., Plaghki, L., 1979. The deficit of the isometric tetanic tension red...
متن کاملCharacterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells
Force development in smooth muscle, as in skeletal muscle, is believed to reflect recruitment of force-generating myosin cross-bridges. However, little is known about the events underlying cross-bridge recruitment as the muscle cell approaches peak isometric force and then enters a period of tension maintenance. In the present studies on single smooth muscle cells isolated from the toad (Bufo m...
متن کاملTRANSLATIONAL PHYSIOLOGY Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation
Rembold, Christopher M., Robert L. Wardle, Christopher J. Wingard, Timothy W. Batts, Elaine F. Etter, and Richard A. Murphy. Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation. Am J Physiol Cell Physiol 287: C594–C602, 2004. First published May 19, 2004; 10.1152/ajpcell.00082.2004.—Serine 19 phosphorylation of the myosin regulatory light...
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ژورنال
عنوان ژورنال: Journal of Muscle Research and Cell Motility
سال: 2015
ISSN: 0142-4319,1573-2657
DOI: 10.1007/s10974-015-9412-6